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Biology · 2026 · 3 marks
Biotechnology and its ApplicationsBiotechnological Applications in Medicine3 marksUnderstandshort answer
CBSE 2026 · Region 4 · Set 1 · Q26
(a) How is insulin different from proinsulin? (b) Explain all the stages of how human insulin is produced through rDNA technology.
(a)
How is insulin different from proinsulin ?
(b)
Explain all the stages of how human insulin is produced through rDNA technology.
Marking-scheme solution
(a)
Proinsulin contains an extra stretch called the C-peptide in addition to chain A and
B / C-peptide is not present in the (mature) insulin.
(b)
Steps to produce insulin through rDNA technology.
Eli Lilly an American Company prepared two DNA sequences corresponding to
A and B chain of human insulin.
These chains A and B were then introduced in plasmid E.coli to produce multiple
copies.
These chains were extracted of separately.
Chain A and B were combined by creating disulphide bonds to form human
insulin.
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CBSE Class 12 Biology past-paper question from the 2026 board exam, with the answer as CBSE’s own marking scheme gives it. Where our answers come from.