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Biology · 2022 · 3 marks
Biotechnology and its ApplicationsBiotechnological Applications in Medicine3 marksUnderstandshort answer
CBSE 2022 · Region 5 · Set 1 · Q11
(a) How does a gene therapy involving direct modification of the cells, in order to achieve a therapeutic goal is used in the treatment of ADA…
(a)
How does a gene therapy involving direct modification of the cells, in order to achieve a therapeutic goal is used in the treatment of ADA deficiency ? Explain.
(b)
A host cell must be made competent, before it is able to receive an rDNA. Justify.
Marking-scheme solution
(a)
Isolation of Lymphocytes from the patients, culturing of Lymphocytes, introduction of functional ADA cDNA into lymphocytes, modified lymphocytes are injected back to the patient.
(b)
DNA molecule being hydrophilic cannot pass through cell membrane
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CBSE Class 12 Biology past-paper question from the 2022 board exam, with the answer as CBSE’s own marking scheme gives it. Where our answers come from.