Hypoxia is a condition in which the oxygen reaching the body tissues falls short of what they need for normal metabolism — a definition brought in from outside, because Chapter $\displaystyle 14$ prints the word only in this exercise and never defines it.
Its usual types, also from outside the chapter:
Hypoxic hypoxia — the arterial \(\displaystyle pO_{2} \) itself is low, as in the thin air of high altitude or where a lung disorder spoils diffusion.
Anaemic hypoxia — enough oxygen reaches the lungs, but too little functional haemoglobin is present to carry it.
Stagnant hypoxia — the blood carries oxygen normally but circulates too sluggishly to deliver it.
Histotoxic hypoxia — oxygen is delivered to the cells, but they cannot use it.
Common signs are breathlessness, faster breathing and heart rate, headache, fatigue and confusion, and a bluish tinge of the skin and lips (cyanosis).
What the chapter supplies for the discussion:
It sets out what a normal oxygen supply depends on: a \(\displaystyle pO_{2} \) gradient of $\displaystyle 104$ mm Hg in the alveoli against $\displaystyle 40$ mm Hg in deoxygenated blood, a diffusion membrane much thinner than a millimetre, and haemoglobin in the RBCs to carry about $\displaystyle 97$ per cent of the \(\displaystyle O_{2} \).
Anything that spoils one of these would leave the tissues short of oxygen. The chapter names three such conditions:
Emphysema — alveolar walls are damaged and the respiratory surface is decreased; cigarette smoking is a major cause.
Asthma — difficulty in breathing with wheezing, due to inflammation of the bronchi and bronchioles.
Occupational respiratory disorders — long exposure to dust in grinding or stone-breaking industries causes inflammation and fibrosis, seriously damaging the lung.
Tie the two together while discussing: emphysema and occupational fibrosis shrink the exchange surface, asthma obstructs the air passages, and a shortage of haemoglobin cripples the $\displaystyle 97$ per cent of \(\displaystyle O_{2} \) the RBCs carry — each one a route to the oxygen shortage defined above.