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Biology · 2026 · 2 marks
CBSE 2026 · Region 3 · Set 3 · Q21
A child is born with a genetic disorder due to the deletion of a gene. (a) Name such a gene studied by you. Explain how gene therapy can help in…
A child is born with a genetic disorder due to the deletion of a gene.
(a)
Name such a gene studied by you. Explain how gene therapy can help in treating such a condition.
(b)
Mention one challenge associated with this therapy.
Marking-scheme solution
(a)
• ADA/ Adenosine Deaminase gene
•
Gene Therapy– A functional copy of the ADA gene is inserted into the isolated and cultured lymphocytes of the patient using a suitable vector like a retrovirus, the corrected cells are then reintroduced into the patient enabling the production of the ADA enzyme and restoring immune function,
(b)
As these lymphocytes are not immortal, the patient requires periodic
infusion of such genetically engineered lymphocytes.
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